T-2 TOXIN EFFECT ON THE ULTRASTRUCTURE OF MYOCARDIAL MICROVASCULATURE

被引：0
|
作者：
YAROM, R
YAGEN, B
机构：
[1] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, SCH PHARM, DEPT PATHOL, IL-91010 JERUSALEM, ISRAEL
[2] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, SCH PHARM, DEPT NAT PROD, IL-91010 JERUSALEM, ISRAEL
来源：
BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY | 1986年 / 67卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The effect of T-2 toxin [from Fusarium] on the ultrastructure of coronary microvasculature was studied in rats injected intraperitoneally and in rats hearts perfused with the toxin. The capillaries were most severely damaged and were often disrupted. The plasma membrane of endothelial cells seemed to be the first structure affected. A direct cytotoxicity of T-2 toxin to the myocardial capillary lining cells seems to be the pathogenical mechanism of injury. The abundance of mast cells in several of the hearts examined suggests a role for their vasoactive products in the genesis of the capillary lesions.
引用
收藏
页码：55 / 63
页数：9
相关论文
共 50 条
  • [31] Review of neurotoxicity of T-2 toxin
    Youshuang Wang
    Bo Wang
    Peilin Wang
    Zeao Hua
    Shanshan Zhang
    Xuebing Wang
    Xu Yang
    Cong Zhang
    Mycotoxin Research, 2024, 40 : 85 - 95
  • [32] DEEPOXY T-2 TETRAOL - A METABOLITE OF T-2 TOXIN FOUND IN COW URINE
    CHATTERJEE, K
    VISCONTI, A
    MIROCHA, CJ
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1986, 34 (04) : 695 - 697
  • [33] EFFECT OF DIETARY T-2 TOXIN ON TRYPTOPHAN-NIACIN METABOLISM
    SASHIDHAR, RB
    RAO, KSJ
    RAO, BSN
    NUTRITION REPORTS INTERNATIONAL, 1988, 37 (04): : 867 - 873
  • [34] ENHANCING EFFECT OF T-2 TOXIN ON DELAYED-HYPERSENSITIVITY IN MICE
    MASUKO, H
    UENO, Y
    OTOKAWA, M
    YAGINUMA, K
    JAPANESE JOURNAL OF MEDICAL SCIENCE & BIOLOGY, 1977, 30 (03): : 159 - 163
  • [35] Protective effect of selenomethionine on intestinal injury induced by T-2 toxin
    Liu, Yumei
    Yang, Yuxiang
    Dong, Ruiqi
    Zhang, Zixiang
    Jia, Fangfang
    Yu, Haotong
    Wang, Yuqin
    Zhang, Ziqiang
    RESEARCH IN VETERINARY SCIENCE, 2020, 132 : 439 - 447
  • [36] Effect of carotenoids on cytotoxicity of T-2 toxin on chicken hepatocytes in vitro
    Leal, M
    De Mejia, EG
    Ruiz, F
    Shimada, A
    TOXICOLOGY IN VITRO, 1998, 12 (02) : 133 - 139
  • [37] IMMUNE STUDIES WITH T-2 TOXIN - EFFECT OF FEEDING AND WITHDRAWAL IN MONKEYS
    JAGADEESAN, V
    RUKMINI, C
    VIJAYARAGHAVAN, M
    TULPULE, PG
    FOOD AND CHEMICAL TOXICOLOGY, 1982, 20 (01) : 83 - 87
  • [38] EFFECT OF T-2 TOXIN ON BOVINE HEMATOLOGICAL AND SERUM ENZYME PARAMETERS
    GENTRY, PA
    ROSS, ML
    CHAN, PKC
    VETERINARY AND HUMAN TOXICOLOGY, 1984, 26 (01) : 24 - 24
  • [39] EFFECT OF FUSARIUM T-2 TOXIN ON HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN THE RABBIT
    GENTRY, PA
    COOPER, ML
    CANADIAN JOURNAL OF COMPARATIVE MEDICINE-REVUE CANADIENNE DE MEDECINE COMPAREE, 1981, 45 (04): : 400 - 405
  • [40] T-2 TOXIN METABOLISM BY RUMINAL BACTERIA AND ITS EFFECT ON THEIR GROWTH
    WESTLAKE, K
    MACKIE, RI
    DUTTON, MF
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1987, 53 (03) : 587 - 592
12345