NOVEL INHIBITORS OF CHOLESTERYL ESTER TRANSFER PROTEIN

被引：14
|
作者：
CHACKALAMANNIL, S
XIA, Y
WANG, YG
TSAI, HG
CZARNIECKI, M
WANG, S
CLEMMONS, A
AHN, HS
BOYKOW, G
机构：
[1] Schering-Plough Research Institute, Kenilworth, NJ 07033
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 17期
关键词：
D O I：
10.1016/0960-894X(95)00342-Q
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and CETP inhibitory activity of a series of compounds related to wiedendiols (1a,1b) are reported. It is proposed that a two point pharmacophore consisting of a catechol group and a large hydrophobic anchor is necessary for activity.
引用
收藏
页码：2005 / 2010
页数：6
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