OXIDIZED LOW-DENSITY LIPOPROTEINS INDUCE IRON RELEASE FROM ACTIVATED MYOGLOBIN

被引：26
|
作者：
RICEEVANS, C
GREEN, E
PAGANGA, G
COOPER, C
WRIGGLESWORTH, J
机构：
[1] UNIV LONDON UNIV COLL,SCH MED,SCH MED,RAYNE INST,DEPT PAEDIAT,LONDON WC1E 6JJ,ENGLAND
[2] KINGS COLL LONDON,CTR MET BIOL & MED,DIV LIFE SCI,LONDON W8 7AH,ENGLAND
来源：
FEBS LETTERS | 1993年 / 326卷 / 1-3期
关键词：
OXIDIZED LDL; MONOHYDROXAMATE; DESFERRIOXAMINE; IRON; MYOGLOBIN; LOW DENSITY LIPOPROTEIN;
D O I：
10.1016/0014-5793(93)81786-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent reports have detected the presence of iron in human atherosclerotic lesions [Biochem. J. 286 (1992) 901-905]. This study provides evidence for a biochemical mechanism whereby iron is released from myoglobin by low density lipoprotein (LDL) which has become oxidised by the ferryl myoglobin species. The haem destabilisation and iron release are inhibited by monohydroxamate compounds and desferrioxamine through their ability to inhibit the propagation of LDL oxidation. Thus, iron may derive from the myoglobin released from ruptured cells in the oxidising environment of the atherosclerotic lesion.
引用
收藏
页码：177 / 182
页数：6
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