MATLYSTATINS, NEW INHIBITORS OF TYPEIV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .2. BIOLOGICAL-ACTIVITIES

被引：24
|
作者：
TANZAWA, K
ISHII, M
OGITA, T
SHIMADA, K
机构：
[1] Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo 140, 1-2-58 Hiromachi, Shinagawa-ku
来源：
JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 11期
关键词：
D O I：
10.7164/antibiotics.45.1733
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Matlystatin A, the main component of matlystatins, inhibits 92kDa and 72kDa typeIV collagenases with IC50 values of 0.3 muM and 0.56 muM, respectively, while 7- to 11-fold greater concentrations are required to inhibit thermolysin and aminopeptidase M. The inhibition is reversible and competitive with respect to gelatin. It inhibits the invasion of basement membrane Matrigel by human fibrosarcoma HT1080 dose-dependently with an IC50 value of 21.6 muM.
引用
收藏
页码：1733 / 1737
页数：5
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