MATLYSTATINS, NEW INHIBITORS OF TYPE-IV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .4. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF MATLYSTATIN-B AND ITS STEREOISOMERS

被引：17

作者：

TAMAKI, K

KURIHARA, S

OIKAWA, T

TANZAWA, K

SUGIMURA, Y

机构：

[1] SANKYO CO LTD,BIOSCI RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

[2] SANKYO CO LTD,FERMENTAT RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 12期

关键词：

D O I：

10.7164/antibiotics.47.1481

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The first total synthesis of matlystatin B (1a), a low molecular weight inhibitor of type IV collagenases, was accomplished, and its absolute configuration was unambiguously determined. Furthermore, ten stereoisomers of 1a were synthesized, and the inhibition of the 92 kDa type IV collagenase and of other metalloproteinases by each stereoisomer was investigated.

引用

页码：1481 / 1492

页数：12

共 2 条

[1] MATLYSTATINS, NEW INHIBITORS OF TYPE-IV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .3. STRUCTURE ELUCIDATION OF MATLYSTATIN-A TO MATLYSTATIN-F
HARUYAMA, H
OHKUMA, Y
NAGAKI, H
OGITA, T
TAMAKI, K
KINOSHITA, T
[J]. JOURNAL OF ANTIBIOTICS, 1994, 47 (12): : 1473 - 1480
[2] MATLYSTATINS, NEW INHIBITORS OF TYPE-IV COLLAGENASES FROM ACTINOMADURA-ATRAMENTARIA .1. TAXONOMY, FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL PROPERTIES OF MATLYSTATIN-GROUP COMPOUNDS
OGITA, T
SATO, A
ENOKITA, R
SUZUKI, K
ISHII, M
NEGISHI, T
OKAZAKI, T
TAMAKI, K
TANZAWA, K
[J]. JOURNAL OF ANTIBIOTICS, 1992, 45 (11): : 1723 - 1732

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