NUTRITION AND PEDIATRIC RHEUMATIC DISEASES - HYPOTHESIS - CYTOKINES MODULATE NUTRITIONAL ABNORMALITIES IN RHEUMATIC DISEASES
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作者:
OSTROV, BE
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PENN STATE UNIV,MILTON S HERSHEY MED CTR,CHILDRENS HOSP,HERSHEY MED CTR,DEPT PEDIAT,HERSHEY,PA 17033PENN STATE UNIV,MILTON S HERSHEY MED CTR,CHILDRENS HOSP,HERSHEY MED CTR,DEPT PEDIAT,HERSHEY,PA 17033
OSTROV, BE
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机构:
[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,CHILDRENS HOSP,HERSHEY MED CTR,DEPT PEDIAT,HERSHEY,PA 17033
Growth abnormalities are common in pediatric rheumatic diseases. Studies suggest that effects of inflammation such as anorexia, and adipose and muscle tissue breakdown contribute to the nutritional and growth aberrations. The effects of the various cytokines produced during inflammation create a vicious cycle of anorexia and increased catabolism, and may be responsible for the nutritional deficits seen. In future, specific treatment with anticytokine monoclonal antibodies may block these effects, minimizing the nutritional consequences of inflammation.