DOSE-DEPENDENT EFFECTS OF DDAVP ON MEMORY IN HEALTHY-YOUNG ADULT MALES - A PRELIMINARY-STUDY

被引：15
|
作者：
BECKWITH, BE [1 ]
TILL, RE [1 ]
RENO, CR [1 ]
POLAND, RE [1 ]
机构：
[1] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT PSYCHIAT,TORRANCE,CA 90509
来源：
PEPTIDES | 1990年 / 11卷 / 03期
关键词：
Behavior; Cortisol; DDAVP; Memory; Neuropeptides; Vasopressin;
D O I：
10.1016/0196-9781(90)90045-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although several studies have demonstrated the efficacy of the vasopressin analog DDAVP in enhancing human memory, no previous study has reported the dose-response relationship of DDAVP to memory in healthy young adults. The present study was undertaken to explore the dose-response curve for DDAVP on recall of implicational sentences. Five doses of DDAVP (0, 5, 15, 30, and 60 μg) were administered intranasally to healthy young adult male volunteers. Results demonstrated a facilitation in cued recall after treatment with the 60-μg dose and a general impairment in recall after treatment with the 15-μg dose. These effects were independent of subject's weight, vocabulary ability, and concentration of salivary cortisol. © 1990.
引用
收藏
页码：473 / 476
页数：4
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