EFFECTS OF PYRIDOXAL 5'-PHOSPHATE ON PLASMA ALANINE AMINOTRANSFERASE DETERMINATIONS IN TOXICOLOGICAL STUDIES

被引：4
|
作者：
EVANS, GO [1 ]
WHITEHORN, LC [1 ]
机构：
[1] WELLCOME RES LABS, DRUG SAFETY EVALUAT, BECKENHAM BR3 3BS, KENT, ENGLAND
来源：
TOXICOLOGY LETTERS | 1995年 / 80卷 / 1-3期
关键词：
PLASMA; RAT; ALANINE AMINOTRANSFERASE; PYRIDOXAL 5'-PHOSPHATE;
D O I：
10.1016/0378-4274(95)03324-E
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Alanine aminotransferase activities (ALT) were measured in rat plasma samples with three different reagent formulations. The inclusion of pyridoxal 5'-phosphate in the reagent produced higher ALT values, and altered the statistical relationships between control and treatment groups in three studies where plasma ALT values were reduced by xenobiotics.
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页码：34 / 37
页数：4
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