EVALUATION OF THE INVITRO AND EXVIVO BLOOD COMPATIBILITY OF PRIMARY REFERENCE MATERIALS

The blood compatibility of the primary reference materials, low density polyethylene and polydimethylsiloxane, was evaluated using human in vitro and human ex vivo test devices, and was compared with that of polyetherurethane and polyvinylchloride. Materials which induced strong in vitro platelet activation, e. g. low density polyethylene and polyvinylchloride, demonstrated high concentrations of fibrinogen and platelets on the surface when tested under ex vivo conditions. Polydimethylsiloxane and polyetherurethane, which induced slight in vitro platelet factor 4 release, adsorbed significantly lower concentrations of fibrinogen and platelets from human native blood.