VINBLASTINE-INDUCED AUTOPHAGY IN MOUSE-LIVER

被引：12

作者：

KROL, T ^{[1
]}

SCHMIDT, M ^{[1
]}

KOLATAJ, A ^{[1
]}

WITEK, B ^{[1
]}

机构：

[1] JAN KOCHANOWSKI UNIV HUMANITIES & SCI, INST BIOL, PL-25518 KIELCE, POLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1994年 / 107卷 / 01期

关键词：

VINBLASTINE; AUTOPHAGY; LIVER;

D O I：

10.1016/1367-8280(94)90023-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vinblastine effect on the size of autophagy in a mouse liver cell was studied. The activity of cathepsin D and L, lysosomal esterase, N-acetylo-beta-glucosaminidase, beta-galactosidase, beta-glucuronidase, acid phosphatase was determined. In an isolated lysosomal fraction, it was found that vinblastine caused an increase of protein degradation of mouse hepatocytes and this action was dependent on dose and time of exposure. It was related to an increase in lysosomal compartment.

引用

页码：165 / 169

页数：5

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