C-FOS ANTISENSE IN THE NUCLEUS-ACCUMBENS BLOCKS THE LOCOMOTOR STIMULANT ACTION OF COCAINE

被引：96
|
作者：
HEILIG, M
ENGEL, JA
SODERPALM, B
机构：
[1] UNIV GOTEBURG,DEPT PSYCHIAT & NEUROCHEM,MOLNDAL,SWEDEN
[2] UNIV GOTEBURG,DEPT PHARMACOL,MOLNDAL,SWEDEN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 236卷 / 02期
关键词：
COCAINE; C-FOS; PSYCHOSTIMULANTS; NUCLEUS ACCUMBENS; REWARD;
D O I：
10.1016/0014-2999(93)90610-T
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Systemic cocaine induces c-fos expression in rat striatum. The functional role of this phenomenon remains unknown. Recently, selective inhibition of gene expression in the brain using antisense oligodeoxynucleotides became possible. Here, we report that bilateral administration of an antisense oligo against c-fos in the nucleus accumbens blocks cocaine induced locomotor stimulation, without affecting spontaneous exploratory activity. A control sense oligo was inactive. This finding suggests a role for c-fos in mediating psychostimulant effects of cocaine.
引用
收藏
页码：339 / 340
页数：2
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