Plexiform fibrohistiocytic tumour has been recently described by Enzinger and Zhang. This is a rare tumour with low grade malignancy which requires large excision. We report two cases, one occurring in a 58-year-old man, presenting a voluminous painless mass of 5 cm on his hand, the other occurring in a 9-year-old boy consulting for a nodule on the chest. On histological examination this dermal hypodermal tumour is characterized by a proliferation of histiocytic-like cells grouped in nodules, where they are associated with multinucleated osteoclastic-like cells and a proliferation of fibroblastic-like cells grouped in fascicles, anastomosing in a plexiform pattern. Immunohistochemistry and ultrastructural aspects are described. Differential diagnosis and histogenesis are discussed.
机构:
Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USA
Ghuman, Marcus
Hwang, Sinchun
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Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USA
Cornell Univ, Weill Med Coll, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USA
Hwang, Sinchun
Antonescu, Cristina R.
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Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USA
Antonescu, Cristina R.
Panicek, David M.
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Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USA
Cornell Univ, Weill Med Coll, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USA