24-HOUR BETA-ENDORPHIN SECRETORY PATTERN IN STROKE PATIENTS

被引:24
|
作者
FRANCESCHINI, R [1 ]
GANDOLFO, C [1 ]
CATALDI, A [1 ]
DELSETTE, M [1 ]
CIANCIOSI, P [1 ]
FINOCCHI, C [1 ]
ROLANDI, E [1 ]
BARRECA, T [1 ]
机构
[1] UNIV GENOA,DEPT NEUROL,I-16143 GENOA,ITALY
关键词
BETA-ENDORPHIN; CORTISONE; CIRCADIAN RHYTHM;
D O I
10.1161/01.STR.25.11.2142
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose Abnormalities of hypothalamopituitary-adrenocortical axis function have been observed frequently in stroke patients. The aim of this study was to investigate plasma beta-endorphin and cortisol 24-hour secretory patterns in patients early after stroke and in the convalescent period to evaluate a possible influence of brain damage on hormonal circadian pattern. Methods Patients (n=15; age, 46 to 75 years) were evaluated in the first 24 hours and 10 days after hospital admission for ischemic cerebral stroke and compared with 15 age- and sex-matched normal subjects. Blood samples for beta-endorphin and cortisol determination were drawn every 4 hours from 8 AM to 8 PM and every 2 hours from midnight to 6 AM. Results Mean 24-hour beta-endorphin and cortisol levels, recorded in the acute phase, were significantly (P<.05) higher than those recorded in normal subjects; circadian rhythm was not demonstrable for either hormone. In the convalescent period, plasma cortisol 24-hour mean values and circadian rhythm returned to the normal range, whereas the plasma beta-endorphin 24-hour mean values and circadian rhythm did not. Conclusions Cerebral stroke induces abnormalities of beta-endorphin and cortisol circadian secretion. Whereas cortisol abnormalities are transient, those of beta-endorphin last longer. The dissociation between beta-endorphin and cortisol 24-hour secretory patterns might potentially serve as a marker of psychoneurological abnormalities occurring after stroke.
引用
收藏
页码:2142 / 2145
页数:4
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