BRAIN-DERIVED NEUROTROPHIC FACTOR EXPRESSION AFTER LONG-TERM POTENTIATION

被引：137
|
作者：
DRAGUNOW, M
BEILHARZ, E
MASON, B
LAWLOR, P
ABRAHAM, W
GLUCKMAN, P
机构：
[1] UNIV AUCKLAND,SCH MED,DEPT PEDIAT,AUCKLAND,NEW ZEALAND
[2] UNIV OTAGO,DEPT PSYCHOL,DUNEDIN,NEW ZEALAND
来源：
NEUROSCIENCE LETTERS | 1993年 / 160卷 / 02期
关键词：
LTP; GROWTH FACTOR; MEMORY; HIPPOCAMPUS; BDNF; RETROGRADE MESSENGER;
D O I：
10.1016/0304-3940(93)90420-P
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.
引用
收藏
页码：232 / 236
页数：5
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