OVEREXPRESSION OF PRAD1 IN A MANTLE ZONE LYMPHOMA PATIENT WITH A T(11 22)(Q13 Q11) TRANSLOCATION

被引：29
|
作者：
KOMATSU, H
YOSHIDA, K
SETO, M
IIDA, S
AIKAWA, T
UEDA, R
MIKUNI, C
机构：
[1] AICHI CANC CTR,RES INST,CHEMOTHERAPY LAB,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN
[2] SAPPORO NATL HOSP,DEPT MED,SHIROISHI KU,SAPPORO,JAPAN
[3] S SAPPORO HOSP,DEPT MED,CHUOH KU,SAPPORO,JAPAN
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1993年 / 85卷 / 02期
关键词：
D O I：
10.1111/j.1365-2141.1993.tb03194.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The PRAD1 gene identified from the chromosome band 11q13 region was previously demonstrated to be overexpressed in cell lines with t(11;14)(q13;q32) translocation and was suggested to be a candidate BCL-1 gene. We report here one case of mantle zone lymphoma with a t(11;22)(q13;q11), a variant translocation at the BCL-1 locus, having the PRAD1 overexpression. By analogy with the c-myc gene in Burkitt's lymphoma and the BCL-2 gene in follicular lymphoma, this case supports strongly the idea that the PRAD1 is the candidate BCL-1 gene.
引用
收藏
页码：427 / 429
页数：3
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