PROBING THE DISTANCE BETWEEN THE 2 BINDING-SITES OF HIRUDIN FOR ITS INTERACTION WITH THE ACTIVE-SITE AND THE FIBRIN(OGEN)-BINDING SITE OF ALPHA-THROMBIN

被引：0

作者：

WAGNER, U

SCHMITZ, T

OTTE, M

DODT, J

机构：

来源：

BIOMEDICA BIOCHIMICA ACTA | 1991年 / 50卷 / 4-6期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of DELTA(Ser50)-hirudin with alpha-thrombin has been investigated. Deletion of Ser50 of r-hirudin caused a 2.7 fold increase of the K(i) for its complex with alpha-thrombin. Determination of the rate constants k(on) and k(off) for complex formation showed that this effect was mainly due to a change in k(off).

引用

页码：707 / 710

页数：4

共 49 条

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