EXTRAHEPATIC TRANSCRIPTION OF PLASMA PREKALLIKREIN GENE IN HUMAN AND RAT-TISSUES

被引：14
|
作者：
CIECHANOWICZ, A
BADER, M
WAGNER, J
GANTEN, D
机构：
[1] UNIV HEIDELBERG,DEPT PHARMACOL,W-6900 HEIDELBERG,GERMANY
[2] MAX DELBRUCK CTR MOLEC MED,BERLIN,GERMANY
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 03期
关键词：
D O I：
10.1006/bbrc.1993.2628
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The expression of plasma prekallikrein (PPK) mRNA has been investigated applying reverse transcription, followed by polymerase chain reaction, of mRNA (RT-PCR) in various human and rat tissues. PPK gene transcripts were detected in liver and kidney in both species and, in addition, in human adrenal gland and placenta. No PPK mRNA was identified in rat adrenal gland, heart, aorta, lung, brain cortex and medulla, hypothalamus, and uterus. These results show that PPK gene expression is not restricted to the liver. © 1993 Academic Press. All rights reserved.
引用
收藏
页码：1370 / 1376
页数：7
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