POTENT, ORALLY-ACTIVE CARBOXYLATE REPLACEMENT ANALOGS OF THE ENDOTHELIN RECEPTOR ANTAGONIST L-749,329

被引：0
|
作者：
FITCH, KJ
WALSH, TF
TOUPENCE, RB
WILLIAMS, DL
NOLAN, NA
OBRIEN, JA
PETTIBONE, DJ
KIVLIGHN, SD
KRAUSE, SM
CLAYTON, FC
ZINGARO, GJ
SIEGL, PKS
GREENLEE, WJ
机构：
[1] MERCK SHARP & DOHME RES LABS,DEPT PHARMACOL,RAHWAY,NJ 07065
[2] MERCK SHARP & DOHME RES LABS,DEPT EXPLORATORY CHEM,RAHWAY,NJ 07065
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1995年 / 209卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：162 / MEDI
相关论文
共 50 条
  • [41] L-159,689 - A POTENT, ORALLY-ACTIVE, NONPEPTIDIC, BALANCED AT1/AT2 ANGIOTENSIN-II ANTAGONIST
    DELASZLO, S
    QUAGLIATO, CS
    GREENLEE, WJ
    PATCHETT, AA
    KIVLIGHN, SD
    CHANG, RS
    SIEGL, PKS
    SCHORN, TS
    FAUST, KA
    CHEN, TB
    ZINGARO, GJ
    LOTTI, VJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 64 - MEDI
  • [42] Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: Potent, orally-active 1,4-disubstituted imidazoles
    Dow, Robert L.
    Hadcock, John R.
    Scott, Dennis O.
    Schneider, Steven R.
    Paight, Ernest S.
    Iredale, Philip A.
    Carpino, Philip A.
    Griffith, David A.
    Hammond, Marlys
    DaSilva-Jardine, Paul
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (18) : 5351 - 5354
  • [43] Structure transport studies to identify an orally active nonpeptide endothelin receptor antagonist
    Smith, PL
    Lee, CP
    Elliott, JD
    Ohlstein, EH
    Fong, KL
    Eddy, EP
    Ellens, H
    Dougherty, P
    Lago, A
    Nambi, P
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 13 - BTEC
  • [44] PHARMACOLOGY OF SC-52458, AN ORALLY-ACTIVE, NONPEPTIDE ANGIOTENSIN-AT(1) RECEPTOR ANTAGONIST
    OLINS, GM
    CORPUS, VM
    CHEN, ST
    MCMAHON, EG
    PALOMO, MA
    MCGRAW, DE
    SMITS, GJ
    NULL, CL
    BROWN, MA
    BITTNER, SE
    KOEPKE, JP
    BLEHM, DJ
    SCHUH, JR
    BAIERL, CJ
    SCHMIDT, RE
    COOK, CS
    REITZ, DB
    PENICK, MA
    MANNING, RE
    BLAINE, EH
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1993, 22 (04) : 617 - 625
  • [45] Design of potent, selective and orally-active NPY Y1 receptor antagonists.
    Valette, G
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 119 - MEDI
  • [46] POTENCY OF THE NOVEL ORALLY-ACTIVE ENDOTHELIN ANTAGONIST RO46-2005 FOR ENDOTHELIN RECEPTORS IN HUMAN VASCULAR SMOOTH-MUSCLE
    MAGUIRE, JJ
    KUC, RE
    OREILLY, G
    DAVENPORT, AP
    BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 : U64 - U64
  • [47] N-3-SUBSTITUTED PYRIMIDINONES AS POTENT ORALLY-ACTIVE AT1RECEPTOR ANTAGONISTS
    SALIMBENI, A
    BRAVI, M
    CALIARI, S
    CANEVOTTI, R
    POMA, D
    RENZETTI, AR
    SCOLASTICO, C
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 75 - MEDI
  • [48] O-PHENYLPHENOLS - POTENT AND ORALLY-ACTIVE LEUKOTRIENE B-4 RECEPTOR ANTAGONISTS
    SOFIA, MJ
    FLOREANCIG, P
    BACH, NJ
    BAKER, SR
    COCKERHAM, SL
    FLEISCH, JH
    FROELICH, LL
    JACKSON, WT
    MARDER, P
    ROMAN, CR
    SAUSSY, DL
    SPAETHE, SM
    STENGEL, PW
    SILBAUGH, SA
    JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (24) : 3978 - 3981
  • [49] SELECTION OF AN ORALLY-ACTIVE GLYCOPROTEIN-IIB/IIIA RECEPTOR ANTAGONIST FOR CLINICAL-TRIALS
    ZABLOCKI, J
    NICHOLSON, N
    TAITE, B
    PANZERKNODLE, S
    SALYERS, A
    HAAS, N
    SZALONY, J
    FEIGEN, L
    HERIN, M
    JACQMIN, P
    LESNE, M
    BOVY, P
    TJOENG, FS
    THROMBOSIS AND HAEMOSTASIS, 1993, 69 (06) : 1244 - 1244
  • [50] THE PHARMACOLOGY OF SCH-50911 - A NOVEL, ORALLY-ACTIVE GABA-B RECEPTOR ANTAGONIST
    BOLSER, DC
    BLYTHIN, DJ
    CHAPMAN, RW
    EGAN, RW
    HEY, JA
    RIZZO, C
    KUO, SC
    KREUTNER, W
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1995, 274 (03): : 1393 - 1398
12345