The retinoblastoma protein: multitasking to suppress tumorigenesis

被引：0
|
作者：
Vormer, Tinke L. [1 ]
Hansen, Jacob B. [2 ]
te Riele, Hein [1 ]
机构：
[1] Netherlands Canc Inst, Div Biol Stress Response, Amsterdam, Netherlands
[2] Univ Copenhagen, Dept Biol, Copenhagen, Denmark
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 01期
关键词：
D O I：
10.4161/23723548.2014.968062
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.
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页数：2
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