SELECTIVE INHIBITORS OF KCL COTRANSPORT IN HUMAN RED-CELLS

被引：34

作者：

ELLORY, JC ^{[1
]}

HALL, AC ^{[1
]}

ODY, SO ^{[1
]}

ENGLERT, HC ^{[1
]}

MANIA, D ^{[1
]}

LANG, HJ ^{[1
]}

机构：

[1] PHARMASYNTHESE HOECHST,FRANKFURT,GERMANY

来源：

FEBS LETTERS | 1990年 / 262卷 / 02期

基金：

英国惠康基金;

关键词：

HbSS; K[!sup]+[!/sup] transport; Red cell;

D O I：

10.1016/0014-5793(90)80193-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two analogues of the loop diuretics furosemide and bumetanide have been identified as differential inhibitors of KCl and NaKCl cotransport systems, assayed by measuring K+ influx in 'young' human red cells. H25 inhibited both NaKCl and KCl cotransport, with I50% values of 0.03 and 30 μM respectively; H74 had no effect on NaKCl cotransport, even at 0.3 mM, but inhibited KCl cotransport with an I50% of 75 μM. These compounds are therefore useful for resolving the two transport systems. © 1990.

引用

页码：215 / 218

页数：4

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