ENANTIOMERICALLY PURE BETA-AMINO SULFIDES AND BETA-AMINO THIOLS FROM EPHEDRINE

被引：0
|
作者：
POELERT, MA
HOF, RP
PEPER, NCMW
KELLOGG, RM
机构：
来源：
HETEROCYCLES | 1994年 / 37卷 / 01期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ephedrine and pseudoephedrine are converted by means of a Mitsunobu reaction to respectively trans- and cis-aziridines, which can be ring-opened at the benzylic center with inversion of configuration by thiols and thiol acids. The trans-aziridine from ephedrine reacts also with H2S in acetone under which conditions the amino thiol is trapped as the thiazolane. The same aziridine also undergoes cycloaddition with CS2.
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页码：461 / 475
页数：15
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