VISCOSITY MEASUREMENTS OF SUSPENSIONS OF HEMOGLOBIN-CONTAINING LIPOSOMES OF VARYING LIPID-COMPOSITION

被引：4
|
作者：
JOPSKI, B
PIRKL, V
SCHMIDT, KH
机构：
[1] Chirurgische Klinik der Universität Tübingen, Calwer Str. 7
来源：
BIOMATERIALS ARTIFICIAL CELLS AND ARTIFICIAL ORGANS | 1990年 / 18卷 / 02期
关键词：
D O I：
10.3109/10731199009117312
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The viscosity of suspensions of hemoglobin-containing liposomes (Hb liposomes) and of liposomes without Hb was determined as a function of the shear rate. Liposomes of varying lipid composition were prepared by detergent dialysis. All liposome suspensions showed non-Newtonian viscous behavior, as did erythrocyte suspensions. The viscosity of suspensions of Hb liposomes with a bilayer consisting of egg yolk lecithin and phosphatidylserine was almost identical to erythrocyte suspension viscosity. When cholesterol was included in the lipid component of the Hb liposomes, the dependence of viscosity on the shear rate decreased (flattening of the curve), but overall suspension viscosity became higher than that of erythrocyte suspensions. Evidence is provided for the lipid concentration at which liposomes can be applied intravenously. © 1990, Informa UK Ltd. All rights reserved.
引用
收藏
页码：345 / 358
页数：14
相关论文
共 50 条
12345