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Johns Hopkins Univ Hosp, Dept Neurol Neurosurg Anesthesia & Crit Care Med, Johns Hopkins Sch Med, Div Neurosci Crit Care, 600 N Wolfe St Phipps 455, Baltimore, MD 21287 USA Johns Hopkins Univ Hosp, Dept Neurol Neurosurg Anesthesia & Crit Care Med, Johns Hopkins Sch Med, Div Neurosci Crit Care, 600 N Wolfe St Phipps 455, Baltimore, MD 21287 USA