TROLOX ATTENUATES CORTICAL NEURONAL INJURY-INDUCED BY IRON, ULTRAVIOLET-LIGHT, GLUCOSE DEPRIVATION, OR AMPA

被引：49

作者：

CHOW, HS

LYNCH, JJ

ROSE, K

CHOI, DW

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT NEUROL, ST LOUIS, MO 63110 USA

[2] WASHINGTON UNIV, SCH MED, CTR STUDY NERVOUS SYST INJURY, ST LOUIS, MO 63110 USA

[3] STANFORD UNIV, DEPT NEUROL & NEUROL SCI, STANFORD, CA 94305 USA

来源：

BRAIN RESEARCH | 1994年 / 639卷 / 01期

关键词：

GLUTAMATE; NEUROTOXICITY; EXCITOTOXICITY; FREE RADICAL; LIPID PEROXIDATION; STROKE; HYPOGLYCEMIA;

D O I：

10.1016/0006-8993(94)91769-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The vitamin E analog, trolox, protected cultured cortical neurons against damage induced by exposure to either iron ions or ultraviolet (UV) light, consistent with an ability to inhibit free radical-mediated cytotoxicity. Trolox also reduced neuronal death induced by 24 h exposure to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), but not that induced by N-methyl-D-aspartate (NMDA). When combined with the NMDA receptor antagonist dextrorphan, trolox also reduced the neuronal injury induced by glucose deprivation.

引用

页码：102 / 108

页数：7

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