INVITRO AND INVIVO STUDIES ON THE EFFECTS OF THE ALPHA-ADRENOCEPTOR BLOCKER IP/66 (1-(2-ETHOXY-2-(3'-PYRIDYL)ETHYL)-4-(2'-METHOXY-PHENYL)PIPERAZINE) ON URETHRAL TONE IN RATS

被引：1
|
作者：
MANZINI, S
PERRETTI, F
BONI, P
BARBANTI, G
TURINI, D
MAGGI, CA
机构：
[1] MENARINI PHARMACEUT, DEPT PHARMACOL, FLORENCE, ITALY
[2] UNIV FERRARA, DEPT SURG PATHOL, I-44100 FERRARA, ITALY
[3] UNIV FERRARA, UROL CLIN, I-44100 FERRARA, ITALY
来源：
DRUG DEVELOPMENT RESEARCH | 1991年 / 23卷 / 01期
关键词：
BENIGN PROSTATIC HYPERTROPHY; ALPHA-ADRENOCEPTOR ANTAGONISTS; PRAZOSIN-; IP/66-URETHRA-PROSTATE;
D O I：
10.1002/ddr.430230104
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
IP/66 (1-(2-ethoxy-2-(3'-pyridyl)ethyl)-4-(2'-methoxy-phenyl)piperazine is a newly synthetized and stereoselective alpha-adrenoceptor blocking drug. This compound exhibits preferential blocking activity in postjunctional as compared to prejunctional alpha-adrenergic responses. Furthermore, IP/66 inhibits phenylephrine-induced motor response in human and rat prostatic tissue and phenylephrine-, DMPP- and EFS-induced motor responses in rat urethral tissues, being equieffective or even more potent than prazosin. Like prazosin, intravenous administration of IP/66, at doses at which no hypotensive effect is observed, induces a marked inhibition of phenylephrine or DMPP-induced increase in urethral perfusion pressure, in anaesthetized pithed rats. Finally, IP/66 administration exerts beneficial effects in animals with surgically- or pharmacologically-induced urethral outflow obstruction. As a whole, the pharmacodynamic profile of IP/66 is promising and this drug might be proposed for clinical setting evaluating its efficacy for the treatment of lower urinary tract dysfunctions.
引用
收藏
页码：35 / 46
页数：12
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