THE TOLERABILITY AND EFFICACY OF THE ATYPICAL NEUROLEPTIC REMOXIPRIDE COMPARED WITH CLOZAPINE AND HALOPERIDOL IN ACUTE SCHIZOPHRENIA

被引:22
|
作者
KLIESER, E [1 ]
STRAUSS, WH [1 ]
LEMMER, W [1 ]
机构
[1] RHEIN LANDES & HSCH KLIN PSYCHIAT ESSEN,DUSSELDORF,GERMANY
关键词
REMOXIPRIDE; CLOZAPINE; SCHIZOPHRENIA SIDE EFFECT;
D O I
10.1111/j.1600-0447.1994.tb05836.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Remoxipride and clozapine are new neuroleptics that are thought to be superior to the substances in use by their efficacy and tolerance. At the University Clinic of Psychiatry in Dusseldorf a double-blind study with 54 patients diagnosed as schizophrenic in accordance with DSM-III was conducted to record the influence of the neuroleptics remoxipride, clozapine and haloperidol on schizophrenic psychosis. The schizophrenic symptoms were rated by the AMDP-system (Arbeitsgemeinschaft fur Methodik und Dokumentation in der Psychiatrie), Brief Psychiatric Rating Scale and the Clinical Global Impression on days 0, 7, 14, 21 and 28 of treatment to evaluate the degree of change in psychopathology. The tolerance of the neuroleptic treatment was checked by the doctor's overall impression and the somatic findings of the AMDP-system. All 3 neuroleptics reduced the schizophrenic symptoms to a similar degree but showed differentiation as to their side effects.
引用
收藏
页码:68 / 73
页数:6
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