MENINGEAL INVOLVEMENT IN BENCE-JONES MULTIPLE-MYELOMA

被引：0

作者：

ODA, K ^{[1
]}

EGAWA, H ^{[1
]}

OKUHARA, T ^{[1
]}

SAKAI, A ^{[1
]}

HYOHDOU, H ^{[1
]}

TANAKA, H ^{[1
]}

KURAMOTO, A ^{[1
]}

机构：

[1] HIROSHIMA UNIV,NUCL MED & BIOL RES INST,HIROSHIMA 730,JAPAN

来源：

CANCER | 1991年 / 67卷 / 07期

关键词：

D O I：

10.1002/1097-0142(19910401)67:7<1900::AID-CNCR2820670714>3.0.CO;2-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case of Bence Jones kappa multiple myeloma with meningeal involvement in a 64-year-old woman is presented. Three years after the diagnosis of multiple myeloma, gait disturbances developed followed by visual disorders and impaired consciousness. A lumbar puncture revealed numerous atypical plasma cells in the cerebrospinal fluid. Craniospinal irradiation and intrathecal injections of methotrexate, cytarabine, and prednisolone were effective for a short period. At autopsy, the leptomeninges were infiltrated diffusely with atypical plasma cells. A review of the literature showed that multiple myeloma with meningeal involvement is accompanied frequently by circulating atypical plasma cells or plasma cell leukemia. Meningeal involvement is a rare complication and shows poor prognosis in cases of multiple myeloma.

引用

页码：1900 / 1902

页数：3

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