iron toxicity;
thalassaemia;
sickle cell disease;
chelation therapy;
drug;
D O I:
10.4081/thal.2014.4860
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
The long term consequences of iron toxicity are mostly reversible with effective iron chelation therapy. Recommendations for use of chelation therapy in transfusion dependent thalassaemia (TDT), sickle cell disease (SCD) and non transfusion dependent thalassaemia (NTDT) continue to evolve as our knowledge and clinical experience increases. Improved chelation options including drug combinations and a better understanding of condition specific factors may help to improve efficiency of chelation regimens and meet the needs of patients more effectively.
机构:
Childrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Res Ctr Oakland, Oakland, CA 94609 USAChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Vichinsky, Elliott P.
Ohene-Frempong, Kwaku
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h-index: 0
机构:
Childrens Hosp Philadelphia, Philadelphia, PA 19104 USAChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Ohene-Frempong, Kwaku
Thein, Swee Lay
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机构:
Kings Coll London, Sch Med, London WC2R 2LS, EnglandChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Thein, Swee Lay
de Castro Lobo, Clarisse Lopes
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机构:
HEMORIO, Rio De Janeiro, BrazilChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
de Castro Lobo, Clarisse Lopes
Inati, Adlette
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h-index: 0
机构:
Rafik Hariri Univ Hosp, Beirut, LebanonChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Inati, Adlette
Thompson, Alexis A.
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h-index: 0
机构:
Childrens Mem Hosp, Chicago, IL 60614 USAChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Thompson, Alexis A.
Smith-Whitley, Kim
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h-index: 0
机构:
Childrens Hosp Philadelphia, Philadelphia, PA 19104 USAChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Smith-Whitley, Kim
Kwiatkowski, Janet L.
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h-index: 0
机构:
Childrens Hosp Philadelphia, Philadelphia, PA 19104 USAChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Kwiatkowski, Janet L.
Swerdlow, Paul S.
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h-index: 0
机构:
Karmanos Canc Inst, Detroit, MI USAChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Swerdlow, Paul S.
Porter, John B.
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h-index: 0
机构:
UCL, London, EnglandChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
Porter, John B.
Marks, Peter W.
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h-index: 0
机构:
Yale Univ, Sch Med, New Haven, CT USAChildrens Hosp, Dept Hematol Oncol, Oakland, CA 94609 USA
机构:
Liverpool Community Hlth NHS Trust, Cent Abacus, Liverpool, Merseyside, EnglandLiverpool Community Hlth NHS Trust, Cent Abacus, Liverpool, Merseyside, England
Jayadeva, Praveen
Albertazzi, Paola
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h-index: 0
机构:
Liverpool Community Hlth NHS Trust, Cent Abacus, Liverpool, Merseyside, EnglandLiverpool Community Hlth NHS Trust, Cent Abacus, Liverpool, Merseyside, England
机构:
Royal Prince Alfred Hosp, Inst Haematol, Sydney, NSW, Australia
Univ Sydney, Bosch Inst, Sydney, NSW 2006, AustraliaRoyal Prince Alfred Hosp, Inst Haematol, Sydney, NSW, Australia
Ho, P. J.
Tay, L.
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h-index: 0
机构:
Royal Adelaide Hosp, Dept Haematol, Adelaide, SA 5000, AustraliaRoyal Prince Alfred Hosp, Inst Haematol, Sydney, NSW, Australia
Tay, L.
Lindeman, R.
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h-index: 0
机构:
Prince Wales Hosp, Dept Haematol, Sydney, NSW, AustraliaRoyal Prince Alfred Hosp, Inst Haematol, Sydney, NSW, Australia
Lindeman, R.
Catley, L.
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h-index: 0
机构:
Mater Hosp, Dept Haematol, Brisbane, Qld, AustraliaRoyal Prince Alfred Hosp, Inst Haematol, Sydney, NSW, Australia
Catley, L.
Bowden, D. K.
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h-index: 0
机构:
Monash Med Ctr, Thalassaemia Serv Victoria, Melbourne, Vic, AustraliaRoyal Prince Alfred Hosp, Inst Haematol, Sydney, NSW, Australia