BINDING OF TROPANE ALKALOIDS TO NICOTINIC AND MUSCARINIC ACETYLCHOLINE RECEPTORS

被引：0

作者：

SCHMELLER, T ^{[1
]}

SPORER, F ^{[1
]}

SAUERWEIN, M ^{[1
]}

WINK, M ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST PHARMAZEUT BIOL,D-69120 HEIDELBERG,GERMANY

来源：

PHARMAZIE | 1995年 / 50卷 / 07期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fourteen tropane and related alkaloids were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. The biogenetic intermediates littorine, 6 beta-hydroxyhyoscyamine, 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine. The quarternary derivatives N-methylatropine and N-methylscopolamine show the highest binding with IC50 values of less than 100 pM and 300 pM, respectively. The tropane alkaloids (including cocaine) also bind to the nicotinic acetylcholine receptor, albeit with much lower affinities.

引用

页码：493 / 495

页数：3

共 50 条

[21] COMPARISON OF ACTION OF ACETYLCHOLINE AND ACETYLCHOLINE MUSTARD (CHLOROETHYL-METHYLAMINOETHYL ACETATE) ON MUSCARINIC AND NICOTINIC RECEPTORS
HUDGINS, PM
STUBBINS, JF
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1972, 182 (02): : 303 - &
[22] Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors
Olsen, Jeppe A.
Balle, Thomas
Gajhede, Michael
Ahring, Philip K.
Kastrup, Jette S.
PLOS ONE, 2014, 9 (03):
[23] MUSCARINIC ACETYLCHOLINE RECEPTORS
UCHIDA, S
TAKEYASU, K
YONEHARA, N
YOSHIDA, H
JAPANESE JOURNAL OF PHARMACOLOGY, 1978, 28 : P22 - P22
[24] RC-4BC cells express nicotinic and muscarinic acetylcholine receptors
Zhubanova, Gulsamal
Filchakova, Olena
PLOS ONE, 2022, 17 (12):
[25] CONTRIBUTION OF NICOTINIC AND MUSCARINIC RECEPTORS IN THE SECRETION OF CATECHOLAMINES EVOKED BY ENDOGENOUS AND EXOGENOUS ACETYLCHOLINE
WAKADE, AR
WAKADE, TD
NEUROSCIENCE, 1983, 10 (03) : 973 - 978
[26] Muscarinic acetylcholine receptors
Ishii, Masaru
Kurachi, Yoshihisa
CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (28) : 3573 - 3581
[27] IDENTIFICATION OF NICOTINIC AND MUSCARINIC ACETYLCHOLINE RECEPTORS IN SUBCELLULAR-FRACTIONS OF MOUSE BRAIN
SCHLEIFER, LS
ELDEFRAWI, ME
NEUROPHARMACOLOGY, 1974, 13 (01) : 53 - 63
[28] Acetylcholine Promotes Binding of α-Conotoxin MII at α3β2 Nicotinic Acetylcholine Receptors
Sambasivarao, Somisetti V.
Roberts, Jessica
Bharadwaj, Vivek S.
Slingsby, Jason G.
Rohleder, Conrad
Mallory, Chris
Groome, James R.
McDougal, Owen M.
Maupin, C. Mark
CHEMBIOCHEM, 2014, 15 (03) : 413 - 424
[29] Acetylcholine-binding proteins - Functional and structural hornologs of nicotinic acetylcholine receptors
Smit, August B.
Celie, Patrick H. N.
Kasheverov, Igor E.
Mordvintsev, Dmitry Y.
van Nierop, Pim
Bertrand, Daniel
Tsetlin, Victor
Sixma, Titia K.
JOURNAL OF MOLECULAR NEUROSCIENCE, 2006, 30 (1-2) : 9 - 10
[30] Nicotinic acetylcholine receptors
Dmitrieva, N
Wang, Y
Lindstrom, JM
Keyser, KT
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1997, 38 (04) : 227 - 227

← 1 2 3 4 5 →