ENHANCED MYCN EXPRESSION AND ISOCHROMOSOME 17Q IN PINEALOBLASTOMA CELL-LINES

被引：22
|
作者：
KEES, UR
BIEGEL, JA
FORD, J
RANFORD, PR
PERONI, SE
HALLAM, LA
PARMITER, AH
WILLOUGHBY, MLN
SPAGNOLO, D
机构：
[1] PRINCESS MARGARET HOSP CHILDREN,DEPT HAEMATOL ONCOL,PERTH,WA,AUSTRALIA
[2] PRINCESS MARGARET HOSP CHILDREN,DEPT ANAT PATHOL,PERTH,WA,AUSTRALIA
[3] CHILDRENS HOSP PHILADELPHIA,DIV HUMAN GENET,PHILADELPHIA,PA 19104
[4] QUEEN ELIZABETH II MED CTR,HOSP PATHOL SERV,PERTH,WA,AUSTRALIA
[5] QUEEN ELIZABETH II MED CTR,UNIV PATHOL SERV,PERTH,WA,AUSTRALIA
来源：
GENES CHROMOSOMES & CANCER | 1994年 / 9卷 / 02期
关键词：
D O I：
10.1002/gcc.2870090209
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have established two cell lines, PER-452 and PER-453, from an 8-month-old girl with an extensive pineoblastoma. Characterization of these lines revealed that the proto-oncogenes MYC and MYCN were not amplified, but both cell lines showed MYCN expression comparable to a cell line with 200-fold MYCN amplification. Both cell lines contained an i(17q). These results support the concept that pineoblastomas belong to a larger group of primitive neuroectodermal tumors of the central nervous system. These two cell lines provide a unique opportunity to investigate the molecular genetic mechanisms underlying these neoplasms further. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码：129 / 135
页数：7
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