EXOGENOUS SUPEROXIDE-DISMUTASE UPTAKE BY THE MYOCARDIUM AND KIDNEY IN AN ISCHEMIC REPERFUSION MODEL IN DOGS

The renal and cardiac tissues of dogs were examined with autoradiographic method in ischaemic reperfusion trials with the aim of studying the access of exogenous superoxide dismutase (SOD) enzyme to the cells. Penetration of SOD into the cells was demonstrated. The enzyme showed special affinity to the mitochondira and myofilaments in the myocardium and it was seen both in the glomeruli and the tubules in the kidney. In both organs the uptake of the enzyme was most abundant in the ischaemic regions than in tissues with intact circulation.