AN ANTIBODY-CATALYZED 1,2-REARRANGEMENT OF CARBON-CARBON BONDS

被引：0
|
作者：
CHEN, YW
REYMOND, JL
LERNER, RA
机构：
[1] SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
[2] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 15-16期
关键词：
D O I：
10.1002/anie.199416071
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The transition state of the dienone‐phenol rearrangement of 1 to 2 is mimicked by hapten 3. An immune response to 3 yielded an antibody (62C7) which was found to catalyze the rearrangement efficiently. It was shown that 62C7 does not act as a simple acid catalyst, but rather selectively stabilizes the charge distribution in the transition state. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany
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页码：1607 / 1609
页数：3
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