COMPARISON OF THE HEMODYNAMIC-EFFECTS OF ENDOTHELIN-1 AND BIG ENDOTHELIN-1 IN THE RAT

被引：8
|
作者：
POLLOCK, DM
OPGENORTH, TJ
机构：
[1] Pharmaceutical Discovery, Abbott Laboratories Abbott Park
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 02期
关键词：
D O I：
10.1016/0006-291X(91)91936-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We compared the hemodynamic effects of continuous i.v. infusion of endothelin-1 and big endothelin-1 in anesthetized rats. Big endothelin-1 was fivefold less potent than endothelin-1 in decreasing cardiac output, heart rate, and stroke volume. However, big endothelin-1 produced a significantly larger increase in mean arterial pressure compared to endothelin-1 at doses that produced identical decreases in cardiac output. These findings support the hypothesis that the hypertensive effects of big endothelin-1 and endothelin-1 are produced by differential effects on systemic vascular resistances. © 1991.
引用
收藏
页码：1122 / 1126
页数：5
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