Oral appliances for the treatment of obstructive sleep apnea (OSA) function by repositioning the lower jaw forward during sleep, which advances the tongue and soft palate, resulting in increased upper airway size. Research has proved the efficacy of oral devices by reducing the apnea index, and improving sleep architecture and daytime sleepiness. Oral appliances are not as effective as continuous positive airway pressure (CPAP) but appear to have a higher compliance rate in patients who prefer them over CPAP. This article offers an overview of the dentist's role in the management of OSA patients with oral appliance therapy.