DESIGN AND SYNTHESIS OF NOVEL PEPTIDES BEARING A HOST AND A GUEST SIDE-CHAINS

被引：10

作者：

VOYER, N

GUERIN, B

机构：

来源：

TETRAHEDRON | 1994年 / 50卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4020(01)80813-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of model heptapeptides bearing a host and a guest side chains at different positions is reported. These peptidic structures were designed in such a way that specific backbone; conformations could be induced and stabilized by cooperative side chain interactions. Although circular dichroism studies demonstrated that intra- and intermolecular host guest interactions are involved in the stabilization of the peptidic conformation, they are not strong enough to induce a complete conformational reorganization.

引用

页码：989 / 1010

页数：22

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