THE DESIGN AND BIOLOGICAL EVALUATION OF A SERIES OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A (HMG-COA) REDUCTASE INHIBITORS RELATED TO DIHYDROMEVINOLIN

被引：3

作者：

BONE, EA ^{[1
]}

CUNNINGHAM, EM ^{[1
]}

DAVIDSON, AH ^{[1
]}

GALLOWAY, WA ^{[1
]}

LEWIS, CN ^{[1
]}

MORRICE, EM ^{[1
]}

REEVE, MM ^{[1
]}

TODD, RS ^{[1
]}

WHITE, IM ^{[1
]}

机构：

[1] BRITISH BIOTECHNOL LTD,DEPT BIOL,OXFORD OX4 5LY,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)81069-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

HMG-CoA reductase inhibitors structurally related to dihydromevinolin have been designed and tested. It has been shown that for high inhibitory potency these compounds must possess a methyl group at the C-7 position, but several different alkenes can be tolerated at the C-3 position. These compounds show good activity both in vitro and in vivo.

引用

页码：223 / 228

页数：6

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