PREPARATION AND REACTION OF 3-OXO-3H-PYRAZOLO[1,5-A]INDOLE DERIVATIVES

被引：0

作者：

SHEN, JK ^{[1
]}

KATAYAMA, H ^{[1
]}

机构：

[1] NIIGATA COLL PHARM, NIIGATA 95021, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 02期

关键词：

3-OXO-3H-PYRAZOLO[1,5-A]INDOLE; MICHAEL ADDITION; KETO-ENOL TAUTOMERIZATION; 3-HYDROXY-4H-PYRAZOLO[1,5-A]INDOLE; DIMERIC PRODUCT; 2-PYRAZOLINE-4,5-DIONE-5-METHIDE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An alternative method to prepare 3-oxo-2-phenyl-3H-pyrazolo[:1,5-a]indoles starting from indoline-2-carboxylic acid was explored. The reaction with nucleophilic agents allowed us to introduce the properly substituted alkyl substituents at C-4 of the 4H-pyrazolo[1,5-a]indoles. The 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) oxidation of these products gave the 3-oxo-2-phenyl-3H-pyrazolo[1,5-a]indole derivatives. Selective keto-enol tautomerizations of these 1,5-diketo-monoene system were observed.

引用

页码：222 / 227

页数：6

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