PREPARATION AND REACTION OF 3-OXO-3H-PYRAZOLO[1,5-A]INDOLE DERIVATIVES

被引：0
|
作者：
SHEN, JK [1 ]
KATAYAMA, H [1 ]
机构：
[1] NIIGATA COLL PHARM, NIIGATA 95021, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 02期
关键词：
3-OXO-3H-PYRAZOLO[1,5-A]INDOLE; MICHAEL ADDITION; KETO-ENOL TAUTOMERIZATION; 3-HYDROXY-4H-PYRAZOLO[1,5-A]INDOLE; DIMERIC PRODUCT; 2-PYRAZOLINE-4,5-DIONE-5-METHIDE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An alternative method to prepare 3-oxo-2-phenyl-3H-pyrazolo[:1,5-a]indoles starting from indoline-2-carboxylic acid was explored. The reaction with nucleophilic agents allowed us to introduce the properly substituted alkyl substituents at C-4 of the 4H-pyrazolo[1,5-a]indoles. The 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) oxidation of these products gave the 3-oxo-2-phenyl-3H-pyrazolo[1,5-a]indole derivatives. Selective keto-enol tautomerizations of these 1,5-diketo-monoene system were observed.
引用
收藏
页码：222 / 227
页数：6
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