Quantitative Study of Cellular Mechanisms of HIV Infection's Pathogenesis

被引：0
|
作者：
Aliev, B. R. [1 ]
Hidirov, B. N. [2 ]
Saidalieva, M. [2 ]
Hidirova, M. B. [2 ]
机构：
[1] Uzbek Inst Virol, Murodov,7, Tashkent 700194, Uzbekistan
[2] Inst Informat, Tashkent 700125, Uzbekistan
来源：
ENGINEERING LETTERS | 2006年 / 13卷 / 03期
关键词：
HIV infection; CD4; lymphocyte; mathematical model; qualitative analysis; irregular oscillations; black hole" effect;
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
CD4 lymphocyte affection underlies in HIV/AIDS infection pathogenesis. In this work we consider some questions of quantitative analysis of CD4 lymphocyte activity at the norm and HIV infection by mathematical modeling. Functional-differential equations for studying regulatory mechanisms of dynamics of CD4 lymphocyte's cellular communities' number have been developed. Results of the qualitative analysis, illustrating possibility of using the developed equations for studying mechanisms of HIV infection's pathogenesis without attraction of the "Hayflick limit" concept are presented. Some questions concerning choice of control ways of dynamics behavior of CD4 lymphocyte's cellular communities' number during HIV infection's pathogenesis are considered.
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