HEME CATABOLISM IN CULTURED-HEPATOCYTES - EVIDENCE THAT HEME OXYGENASE IS THE PREDOMINANT PATHWAY AND THAT A PROPORTION OF SYNTHESIZED HEME IS CONVERTED RAPIDLY TO BILIVERDIN

被引:37
|
作者
LINCOLN, BC
AW, TY
BONKOVSKY, HL
机构
[1] EMORY UNIV,DEPT BIOCHEM,1364 CLIFTON RD NE,ATLANTA,GA 30322
[2] EMORY UNIV,DEPT MED,ATLANTA,GA 30322
关键词
D O I
10.1016/0304-4165(89)90049-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:49 / 58
页数:10
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  • [1] HEPATIC HEME CATABOLISM IN CULTURED-HEPATOCYTES
    LINCOLN, BC
    BONKOVSKY, HL
    FEDERATION PROCEEDINGS, 1987, 46 (06) : 2264 - 2264
  • [2] EFFECTS OF DIPHENYL ETHER HERBICIDES ON THE HEME PATHWAY IN CULTURED-HEPATOCYTES
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    JACOBS, JM
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    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 147 - AGRO
  • [3] EFFECTS OF HEMOPEXIN ON HEME-MEDIATED REPRESSION OF 5-AMINOLEVULINATE SYNTHASE AND INDUCTION OF HEME OXYGENASE IN CULTURED-HEPATOCYTES
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    HEPATOLOGY, 1994, 20 (03) : 741 - 746
  • [4] The Heme Oxygenase/Biliverdin Reductase Pathway in Drug Research and Development
    Mancuso, C.
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  • [5] INDUCTION OF HEME OXIDATION IN VARIOUS TISSUES BY TRACE-METALS - EVIDENCE FOR CATABOLISM OF ENDOGENOUS HEME BY HEPATIC HEME OXYGENASE
    MAINES, MD
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    ANNALS OF CLINICAL RESEARCH, 1976, 8 : 39 - 46
  • [6] Evidence for involvement of protein phosphatases in the induction of heme oxygenase mRNA by heme in cultured liver cells.
    Gildemeister, OS
    Pepe, JA
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    HEPATOLOGY, 1996, 24 (04) : 941 - 941
  • [7] EVIDENCE FOR A RAPIDLY TURNED OVER POOL OF HEME IN ISOLATED HEPATOCYTES
    LODOLA, A
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    FEBS LETTERS, 1978, 90 (02) : 250 - 254
  • [8] Protein/Protein Interactions in the Mammalian Heme Degradation Pathway HEME OXYGENASE-2, CYTOCHROME P450 REDUCTASE, AND BILIVERDIN REDUCTASE
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  • [10] Effects of zinc protoporphyrin IX, a heme oxygenase inhibitor, on mitochondrial membrane potential in rat cultured hepatocytes
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