Disorders in the structural and metabolic organization of liver acini in systemic endotoxemia

被引：0
|
作者：
Shchegolev, AI [1 ]
Yavolov, SP [1 ]
Mishnev, OD [1 ]
机构：
[1] RUSSIAN STATE MED UNIV,FAC THERAPEUT,DEPT PATHOL ANAT,MOSCOW 117437,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 120卷 / 12期
关键词：
liver acinus; metabolism; endotoxin;
D O I：
10.1007/BF02445587
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Injection of Escherichia coli lipopolysaccharide to dogs caused pronounced structural and metabolic changes of liver acini, characterized by the development of compensatory reactions to the endotoxin followed by their failure. In addition to hypoxia, depressed activity of hepatocyte dehydrogenases and diaphorases with impairment of the intraacinar gradient of their activity, leading to the development of hepatocellular insufficiency, appears to underlie the involvement of the liver in systemic endotoxemia.
引用
收藏
页码：1254 / 1257
页数：4
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