SINGLE-CHANNEL ANALYSIS OF TETRODOTOXIN-SENSITIVE AND TETRODOTOXIN-RESISTANT SODIUM-CHANNELS IN RAT DORSAL-ROOT GANGLION NEURONS

被引：25
|
作者：
ROY, ML [1 ]
REUVENY, E [1 ]
NARAHASHI, T [1 ]
机构：
[1] NORTHWESTERN UNIV, SCH MED, DEPT PHARMACOL, CHICAGO, IL 60611 USA
来源：
BRAIN RESEARCH | 1994年 / 650卷 / 02期
关键词：
DORSAL ROOT GANGLION; TETRODOTOXIN; SODIUM CHANNEL; SINGLE SODIUM CHANNEL; TETRODOTOXIN-RESISTANT SODIUM CHANNEL;
D O I：
10.1016/0006-8993(94)91803-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Tetrodotoxin-sensitive and tetrodotoxin-resistant single sod:um channel currents were recorded from rat dorsal root ganglion neurons. The two types of sodium channel currents could be distinguished by the effects of predepolarization, 10 nM tetrodotoxin, and the inactivation during depolarization. Single-channel conductances were calculated to be 6.3 and 3.4 pS in the tetrodotoxin-sensitive and tetrodotoxin-resistant channels, reflectively.
引用
收藏
页码：341 / 346
页数：6
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