PLATELET [H-3] PAROXETINE BINDING IN PANIC DISORDER

被引：10
|
作者：
MAGUIRE, KP
NORMAN, TR
APOSTOLOPOULOS, M
JUDD, FK
BURROWS, GD
机构：
[1] Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg
来源：
JOURNAL OF AFFECTIVE DISORDERS | 1995年 / 33卷 / 02期
基金：
英国医学研究理事会;
关键词：
PANIC DISORDER; PAROXETINE BINDING; PLATELET; SEROTONIN;
D O I：
10.1016/0165-0327(94)00081-J
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Platelet [H-3]paroxetine binding was measured in 20 patients (14 females, six males) with panic disorder and 20 normal controls (14 females, six males). For patients with panic disorder, B-max was 1987 +/- 1135 fmol/mg protein (mean +/- SD) compared with control B-max values of 1626 +/- 611 fmol/mg protein. The mean K-d value for the patients was 0.076 +/- 0.056 nM and for the controls was 0.083 +/- 0.033 nM. ANCOVA indicated no significant effect of sex, diagnosis (panic disorder vs. normal controls) or season of sampling on either K-d or B-max. The data provide no evidence for an abnormality of the platelet uptake mechanism in panic disorder.
引用
收藏
页码：117 / 122
页数：6
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