THE PHENOTYPE AND RECONSTITUTION OF IMMUNOREGULATORY T-CELL SUBSETS AFTER T-CELL-DEPLETED ALLOGENEIC AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION

被引:36
|
作者
SUGITA, K
SOIFFER, RJ
MURRAY, C
SCHLOSSMAN, SF
RITZ, J
MORIMOTO, C
机构
[1] DANA FARBER CANC INST,DIV TUMOR IMMUNOL,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
关键词
D O I
10.1097/00007890-199405270-00012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In the present study, we examined changes in the expression of CD45RA, CD31, and CD29 on total CD4 and CD8 lymphocytes in patients who had received CD6 T cell-depleted allogeneic marrow and received no immune suppressive drugs after engraftment in order to identify defects in reconstitution of immunoregulatory T cells after allogeneic BMT. Results following allo-BMT were compared with normal controls and patients following autologous BMT. We showed that CD4(+)CD45RA(+), CD4(+)CD29(+) (CD29(high)), and CD4(+)CD31(+) cells were markedly decreased during the first 24 months after allo- and auto-BMT. CD8(+)CD45RA(+) cells recovered to normal levels within the first month after auto-BMT, while after allo-BMT, the CD8(+)CD45RA(+) cells were at slightly low levels during the first month, but gradually increased to normal levels by 12 months post-BMT. CD8(+)CD29(+) cells were increased during the first 12 months both after allo- and auto-BMT although during the first month, a decreased percentage of CD8(+)CD29(+) cells was observed in allo-BMT patients. More important, CD4(+)CD29(+), CD8(+)CD29(+), and CD8(+)S6F1(+) cells were significantly increased in patients with moderate-to-severe acute GVHD (grades II-IV) compared with those with or without mild acute GVHD (grade I), suggesting that CD4 helper-inducer (CD4(+)CD29(high)) and CD8 killer-effector (CD8(+)CD29(high)SGF1(+)) cells play an important role in the pathophysiology of acute GVHD.
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收藏
页码:1465 / 1473
页数:9
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