5-HT RECEPTORS IN HUMAN AND ANIMAL CEREBROVASCULATURE

被引：68
|
作者：
PARSONS, AA [1 ]
机构：
[1] UNIV MUNICH, INST PHYSIOL, W-8000 MUNICH 2, GERMANY
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1991年 / 12卷 / 08期
关键词：
D O I：
10.1016/0165-6147(91)90583-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
5-HT has been implicated in the pathogenesis of cerebral arterial vasospasm following subarachnoid haemorrhage and in the aetiology of migraine. Within the cerebrovasculature, 5-HT possesses a complex action dependent on the type of 5-HT receptors present. In this review, Andrew Parsons analyses the evidence demonstrating contractile and relaxant 5-HT receptors within different areas of the cerebrovasculature, and examines differences between human and animal cerebral arteries. The extensive regional and species differences are important considerations for the development of future therapeutic agents in cerebrovascular disease.
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页码：310 / 315
页数：6
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