Lipofundin 20% induces hyperlipidemia and oxidative stress in male Sprague Dawley rats

被引：0

作者：

DelgadoRoche, L. ^{[1
]}

FragaPerez, A. ^{[1
]}

BequerViart, M. A. ^{[1
]}

Hernandez-Matos, Y. ^{[1
]}

机构：

[1] Univ Havana, Pharm & Food Sci Coll, Ctr Studies Res & Biol Evaluat, Havana, Cuba

来源：

VETERINARY WORLD | 2012年 / 5卷 / 03期

关键词：

Lipofundin 20%; hyperlipidemia; oxidative stress; parenteral nutrition;

D O I：

10.5455/vetworld.2012.133-137

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Lipofundin is a lipid emulsion used in parenteral nutrition. One of adverse effects reported for this kind of pharmaceutical products is the capacity to induce oxidative stress, which is an important contributor of many diseases, such as cardiovascular diseases. The aim of the present work was to evaluate the effects of Lipofundin administration on lipid profile and serum redox biomarkers, in order to determine if both events are responsible for the undesirable effects of this lipid emulsion. Male Sprague Dawley rats were intravenously administered with 2 mL/kg of Lipofundin 20% daily, for 8 days. Then, serum lipid profile and redox biomarkers were spectrophotometrically determined. A significant increase ( p<0,05) of serum lipids and biomolecules damages was observed at the end of the experiment, while a reduction of antioxidant capacity was also detected in treated rats compared with controls. Our data demonstrated that Lipofundin 20% induces hyperlipidemia, which promotes an oxidative stress state in Sprague Dawley rats.

引用

页码：133 / 137

页数：5

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