SRC-RELATED PROTEIN TYROSINE KINASES AND T-CELL RECEPTOR SIGNALING

被引：73
|
作者：
VEILLETTE, A
DAVIDSON, D
机构：
[1] MCGILL UNIV,MCGILL CANC CTR,DEPT BIOCHEM,MONTREAL H3A 2T5,QUEBEC,CANADA
[2] MCGILL UNIV,MCGILL CANC CTR,DEPT ONCOL,MONTREAL H3A 2T5,QUEBEC,CANADA
[3] MONTREAL GEN HOSP,DEPT MED,MONTREAL H3G 1Y6,QUEBEC,CANADA
来源：
TRENDS IN GENETICS | 1992年 / 8卷 / 02期
关键词：
D O I：
10.1016/0168-9525(92)90045-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Upon antigen stimulation, the T-cell receptor for antigen transduces an intracellular protein tyrosine phosphorylation signal that is critical for subsequent T-lymphocyte activation. As the antigen receptor does not possess an intrinsic protein tyrosine kinase activity, the mechanism by which it regulates protein tyrosine phosphorylation is unconventional. Evidence is increasing that the Src-related protein tyrosine kinases p56tcr and p59fyn, as well as the protein tyrosine phosphatase CD45, are involved in this process.
引用
收藏
页码：61 / 66
页数：6
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