HUMAN INTERFERON-INDUCIBLE PROTEIN-10 IS A POTENT INHIBITOR OF ANGIOGENESIS IN-VIVO

被引：585

作者：

ANGIOLILLO, AL

SGADARI, C

TAUB, DD

LIAO, F

FARBER, JM

MAHESHWARI, S

KLEINMAN, HK

REAMAN, GH

TOSATO, G

机构：

[1] CHILDRENS NATL MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20010

[2] US FDA,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892

[3] NCI,FREDERICK CANC RES & DEV CTR,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21702

[4] NIAID,CLIN INVEST LAB,BETHESDA,MD 20892

[5] NIDR,DEV BIOL LAB,BETHESDA,MD 20892

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1995年 / 182卷 / 01期

关键词：

D O I：

10.1084/jem.182.1.155

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human interferon-inducible protein 10 (IP-10), a member of the alpha chemokine family, inhibits bone marrow colony formation, has antitumor activity in vivo, is chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells. Here we report that IP-10 is a potent inhibitor of angiogenesis in vivo. IP-10 profoundly inhibited basic fibroblast growth factor-induced neovascularization of Matrigel (prepared by H. K. Kleinman) injected subcutaneously into athymic mice. In addition, IP-10, in a dose-dependent fashion, suppressed endothelial cell differentiation into tubular capillary structures in vitro. IP-10 had no effect on endothelial cell growth, attachment, and migration as assayed in vitro. These results document an important biological property of IP-10 and raise the possibility that IP-10 may participate in the regulation of angiogenesis during inflammation and tumorigenesis.

引用

页码：155 / 162

页数：8

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