ULCERATED HEMANGIOMA SUCCESSFULLY TREATED WITH INTERFERON ALFA-2B AND TOPICAL GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR

被引：11
|
作者：
ILLUM, N [1 ]
KARLSMARK, T [1 ]
SVEJGAARD, E [1 ]
ULLMAN, S [1 ]
YSSING, M [1 ]
机构：
[1] RIGSHOSP,DEPT DERMATOL H,DK-2100 COPENHAGEN O,DENMARK
来源：
DERMATOLOGY | 1995年 / 191卷 / 04期
关键词：
ULCER HEALING; RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (RHGM-CSF); HEMANGIOMA; INTERFERON ALFA-2B;
D O I：
10.1159/000246583
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Objective: We tested whether healing and regression could be promoted by granulocyte-macrophage colony-stimulating factor and interferon in a 6-month-old girl with an ulcerated haemangioma resistant to systemic steroid therapy. Methods: Interferon alfa-ab (Introna, Schering-Plough) was given subcutaneously once daily at a dose of 3 million units/m(2) for 5.5 months and rhGM-CSF (Molgramostim, Leucomax; Sandoz/Schering-Plough) 3.33 units was applied on the wound surfaces once and concomitantly with the initiation of interferon therapy. Results: rue ulcer healed completely within 1 month and the haemangioma almost totally regressed within 6 months. Conclusion: Local application of rhGM-CSF appears to be effective in promoting ulcer healing in an ulcerated haemangioma otherwise responding to interferon treatment.
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页码：315 / 317
页数：3
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