DEVELOPMENT, ESTIMATION AND VALIDATION OF GLIMEPIRIDE IN PHARMACEUTICAL FORMULATION BY HPLC METHOD

被引：1
|
作者：
Maslarska, Vania [1 ]
机构：
[1] Med Univ Sofia, Fac Pharm, Dept Chem, Sofia, Bulgaria
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2014年 / 5卷 / 08期
关键词：
HPLC; Glimepiride (GLM); Tablets; Method Validation;
D O I：
10.13040/IJPSR.0975-8232.5(8).3195-98
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The study is focused on developing a simple, rapid, validated High Performance Liquid Chromatographic ( HPLC) method for Glimepiride Tablets from their dosage forms. The detection was carried out at 230 nm using Shimadzu UV - Visible detector HPLC system. The accuracy and precision were determined and validated statistically. The linearity was observed in the range of 15-120 mu g/mL with a correlation coefficient of 0.999. The limit of detection and the limit of quantification were found to be 4 ng and 10 ng respectively. A Lichrosorb (R) (RP-18 column with a mobile phase consisting of acetonitrile - water - glacial acetic acid (550:450:0.6 v/v)) was used. The flow rate was 1 mL/min. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical industry quality control laboratories.
引用
收藏
页码：3195 / 3198
页数：4
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